Publication: Rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet
Loading...
Date
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
Journal ISSN
Volume Title
Publisher
Soc Brasileira Nefrologia
Type
Article
Access right
Abstract
Introduction: Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and contains significant amount of antioxidants. The aim of this study was to evaluate the preventive effect of RB on renal disease risk factors. Methods: Male Wistar rats (+/- 325 g) were divided into two experimental groups to received a high sugar-fat diet (HSF, n = 8) or high sugar-fat diet with rice bran (HSF + RB, n = 8) for 20 weeks. At the end, renal function, body composition, metabolic parameters, renal inflammatory and oxidative stress markers were analyzed. Results: RB prevented obesity [AI (HSF= 9.92 +/- 1.19 vs HSF + RB= 6.62 +/- 0.78)], insulin resistance [HOMA (HSF= 83 +/- 8 vs. HSF + RB= 42 +/- 11)], dyslipidemia [TG (HSF= 167 +/- 41 vs. HSF + RB=92 +/- 40)], inflammation [TNF-a (HSF= 80 +/- 12 vs. HSF + RB=57 +/- 14), IL-6 (903 +/- 274 vs. HSF + RB=535 +/- 277)], oxidative stress [protein carbonylation (HSF= 3.38 +/- 0.18 vs. HSF + RB=2.68 +/- 0.29), RAGE (HSF=702 +/- 36 vs. RSF + RB=570 +/- 190)], and renal disease [protein/creatinine ratio (HSF=1.10 +/- 0.38 vs. HSF + RB=0.49 +/- 0.16)]. Conclusion: In conclusion, rice bran prevented renal disease by modulating risk factors.
Description
Keywords
Kidney Function Tests, Phytochemicals, Inflammation, Oxidative Stress
Language
English
Citation
Jornal Brasileiro De Nefrologia. Sao Paulo: Soc Brasileira Nefrologia, v. 43, n. 2, p. 156-164, 2021.
