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Effects of dexmedetomidine on renal system and on vasopressin plasma levels. Experimental study in dogs

dc.contributor.authorVillela, Nivaldo Ribeiro [UNESP]
dc.contributor.authorDo Nascimento Jr., Paulo [UNESP]
dc.contributor.authorDe Carvalho, Lídia Raquel [UNESP]
dc.contributor.authorTeixeira, Andrey [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T20:01:15Z
dc.date.available2022-04-28T20:01:15Z
dc.date.issued2005-01-01
dc.description.abstractBACKGROUND AND OBJECTIVES: Perioperative acute renal failure increases morbidity and mortality. Alpha2-adrenergic agonists used in anesthesia increase urinary output and maintain cardiovascular stability. This study aimed at investigating the effects of dexmedetomidine on renal system and on vasopressin plasma levels in anesthetized dogs. METHODS: This study involved 36 adult mixed-breed dogs anesthetized with propofol, fentanyl, and isoflurane, which were randomly distributed in three groups receiving: G1 -20 mL of 0.9% saline in 10 minutes, followed by 20 mL of the same solution in one hour; G2 -20 mL of 0.9% saline with dexmedetomidine (1 μg.kg-1) in 10 minutes, followed by 20 mL of the same solution with the same dexmedetomidine dose (1 μg.kg-1) in one hour; and G3 -20 mL of 0.9% saline with dexmedetomidine (2 μg.kg-1) in 10 minutes, followed by 20 mL of the same solution with the same dexmedetomidine dose (2 μg.kg-1) in one hour. Renal and hemodynamic variables and vasopressin plasma levels were studied in four periods: M1 (control) - immediately after the stabilization period; M2 - after initial injection of the solution being studied, coinciding with the beginning of continuous injection of the same solution; M3 - 30 minutes after M2; and M4 - 30 minutes after M3. RESULTS: Dexmedetomidine has decreased heart rate and maintained adequate cardiovascular stability, as cardiac output was kept constant. Urinary output was increased for G2 and G3 as compared to G1. For G2 and G3, urinary osmolality has decreased in M3 and M4. For G3, values of free water clearance were increased throughout the experiment. Vasopressin plasma levels have decreased for G3, resulting in lower values as compared to G1 and G2 in M2 and M4. CONCLUSIONS: In anesthetized dogs, low doses of dexmedetomidine inhibit vasopressin secretion, causing aqueous diuresis. These actions might protect kidneys during ischemic events. © Sociedade Brasileira de Anestesiologia, 2005.en
dc.description.affiliationFMB - UNESP
dc.description.affiliationDepartamento de Anestesiologia FMB - UNESP
dc.description.affiliationDepartamento de Bioestatística Instituto de Biociências de Botucatu UNESP
dc.description.affiliationFaculdade de Veterinária de Botucatu UNESP
dc.description.affiliationUnespFMB - UNESP
dc.description.affiliationUnespDepartamento de Anestesiologia FMB - UNESP
dc.description.affiliationUnespDepartamento de Bioestatística Instituto de Biociências de Botucatu UNESP
dc.description.affiliationUnespFaculdade de Veterinária de Botucatu UNESP
dc.format.extent429-440
dc.identifier.citationRevista Brasileira de Anestesiologia, v. 55, n. 4, p. 429-440, 2005.
dc.identifier.issn0034-7094
dc.identifier.scopus2-s2.0-22744459619
dc.identifier.urihttp://hdl.handle.net/11449/224579
dc.language.isoeng
dc.language.isospa
dc.relation.ispartofRevista Brasileira de Anestesiologia
dc.sourceScopus
dc.subjectAnimals: dogs
dc.subjectRenal system: vasopressin
dc.titleEffects of dexmedetomidine on renal system and on vasopressin plasma levels. Experimental study in dogsen
dc.titleEfeitos da dexmedetomidina sobre o sistema renal e sobre a concentração plasmática do hormônio antidiurético. Estudo experimental em cãeses
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentAnestesiologia - FMBpt
unesp.departmentBioestatística - IBBpt

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