Advances in prodrug design
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Bentham Science Publishers
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The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT (Polymer-Directed Enzyme Prodrug Therapy); PELT (Polymer-Enzyme Liposome Therapy); CDS (Chemical Delivery System); ADEPT(Antibody-Directed Enzyme Prodrug Therapy); GDEPT/VDEPT (Gene-Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy); ODDS (Osteotropic Drug Delivery System) and LEAPT (Lectin-directed enzyme-activated prodrug therapy) are briefly described and some examples are given. © 2005 Bentham Science Publishers Ltd.
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Latent advanced systems Macromolecules carriers Prodrug design Selective delivery systems aminosalicylic acid ampicillin antiinflammatory agent antileishmanial agent antimalarial agent antineoplastic agent bisphosphonic acid derivative cytochrome P450 diclofenac doxorubicin flucytosine ibuprofen irinotecan isoniazid ketoprofen mevinolin mitomycin nitrofural paclitaxel derivative photosensitizing agent prodrug salazosulfapyridine tacrolimus testosterone derivative tiaprofenic acid tolmetin trigonelline tryptamine derivative unindexed drug antibody directed enzyme prodrug therapy bactericidal activity binding affinity blood brain barrier Chagas disease diarrhea drug absorption drug activation drug design drug distribution drug identification drug receptor binding drug screening drug selectivity drug stability drug structure drug synthesis drug targeting drug transformation gastrointestinal toxicity gene expression human hypercholesterolemia in vivo study macromolecule malaria minimum inhibitory concentration nephrotoxicity organoleptic property osteoporosis review rheumatoid arthritis structure activity relation structure analysis tuberculosis ulcerative colitis Animals Antibodies Drug Carriers Drug Delivery Systems Drug Design Gene Therapy Humans Lectins Macromolecular Substances Osteoporosis Prodrugs Viruses
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Mini-Reviews in Medicinal Chemistry, v. 5, n. 10, p. 893-914, 2005.
