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Effects of chronic stress on nicotine-induced locomotor activity and corticosterone release in adult and adolescent rats

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dc.contributor.authorCruz, Fabio C. [UNESP]
dc.contributor.authorDeLucia, Roberto
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:25:34Z
dc.date.available2014-05-20T13:25:34Z
dc.date.issued2008-03-01
dc.description.abstractWe examined nicotine-induced locomotion and increase in corticosterone plasma levels in adolescent and adult animals exposed to chronic restraint stress. Adolescent [postnatal day (P) 28-37] and adult (P60-67) rats were restrained for 2 hours once daily for 7 days. Three days after the last exposure to stress, the animals were challenged with saline or nicotine (0.4 mg/kg subcutaneously). Nicotine-induced locomotion was recorded in an activity cage. Trunk blood samples were collected in a subset of adolescent and adult rats and plasma corticosterone levels were determined by radioimmunoassay. Exposure to stress did not affect the nicotine-induced locomotor- or corticosterone-activating effects in both ages.en
dc.description.affiliationUNESP, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Lab Psychopharmacol, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.format.extent63-69
dc.identifierhttp://dx.doi.org/10.1111/j.1369-1600.2007.00080.x
dc.identifier.citationAddiction Biology. Oxford: Blackwell Publishing, v. 13, n. 1, p. 63-69, 2008.
dc.identifier.doi10.1111/j.1369-1600.2007.00080.x
dc.identifier.issn1355-6215
dc.identifier.lattes2514762545280942
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.urihttp://hdl.handle.net/11449/8112
dc.identifier.wosWOS:000252927900008
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofAddiction Biology
dc.relation.ispartofjcr5.578
dc.relation.ispartofsjr1,952
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.subjectcorticosteroneen
dc.subjectcross-sensitizationen
dc.subjectlocomotor activityen
dc.subjectnicotineen
dc.subjectraten
dc.subjectstressen
dc.titleEffects of chronic stress on nicotine-induced locomotor activity and corticosterone release in adult and adolescent ratsen
dc.typeArtigopt
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Publishing
dspace.entity.typePublication
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes2514762545280942[3]
unesp.author.orcid0000-0002-1378-6327[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentPrincípios Ativos Naturais e Toxicologia - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas