Publication: Oral health, diabetes, and body weight
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Coadvisor
Graduate program
Undergraduate course
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Article
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Acesso aberto
Abstract
Objectives The effects of apical periodontitis (AP) and periodontal disease (PD) on organ weights in rats with diabetes mellitus (DM) were evaluated. Design Eighty male rats (Rattus norvegicus albinus, Wistar) were divided into eight groups of ten: normoglycemic (N), AP, PD, AP + PD, DM, DM + AP, DM + PD, and DM + AP + PD. DM was induced by streptozotocin; AP, by dental exposure to the oral environment; and PD, by periodontal ligature. Blood glucose concentration was measured at 0, 6, 15, and 35 days; body weight, measured daily; and animals were sacrificed after 30 days after induction of oral infections. Liver, kidney, pancreas, brain, heart, lungs, and gonads were each weighed. Glycemia, feed intake, organ weight, and body weight were subjected to statistical analyses (p < 0.05). Results Glycemic levels were higher in all diabetic groups after day 6, but were consistently similar in normoglycemic groups. Blood glucose was higher in DM + PD and DM + AP + PD groups than in the DM group at days 15 and 35. The feed intake was similar among all groups. Brain, heart, and gonad weights were significantly increased in DM + AP + PD. Kidney and lung weights were increased in DM, regardless of the presence of oral infections. Liver weight was reduced in AP and/or PD. Pancreas weight was reduced in DM, independent of AP or PD. Among the normoglycemic groups, there were no significant differences among organ weights. Conclusion Apical periodontitis and periodontal disease may potentiate the adverse effects of diabetes.
Description
Keywords
Apical periodontitis, Diabetes mellitus, Organ weight, Periodontal disease
Language
English
Citation
Archives of Oral Biology, v. 73, p. 94-99.
