Publicação:
Mushroom-derived preparations in the prevention of H2O2-induced oxidative damage to cellular DNA

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dc.contributor.authorRocha, Noeme Sousa [UNESP]
dc.contributor.authorBarbisan, Luis Fernando [UNESP]
dc.contributor.authorDe Oliveira, Maria Luiza Cotrim [UNESP]
dc.contributor.authorDe Camargo, Joo Lauro Viana [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:20:25Z
dc.date.available2014-05-27T11:20:25Z
dc.date.issued2002-03-06
dc.description.abstractAqueous extracts of the sporophores of eight mushroom species were assessed for their ability to prevent H2O2-induced oxidative damage to cellular DNA using the single-cell gel electrophoresis (Comet) assay. The highest genoprotective effects were obtained with cold (20°C) and hot (100°C) water extracts of Agaricus bisporus and Ganoderma lucidum fruit bodies, respectively. No protective effects were observed with Mushroom Derived Preparations (MDPs) from Flammulina velutipes, Auricularia auricula, Hypsizygus marmoreus, Lentinula edodes, Pleurotus sajor-caju, and Volvariella volvacea. These findings indicate that some edible mushrooms represent a valuable source of biologically active compounds with potential for protecting cellular DNA from oxidative damage. © 2002 Wiley-Liss, Inc.en
dc.description.affiliationDepartamento de Clnica Veterinria Faculdade de Medicina Veterinria e Zootecnia UNESP, Botucatu
dc.description.affiliationDepartamento de Morfologia Instituto de Biologia UNESP, Botucatu
dc.description.affiliationDepartamento de Patologia Faculdade de Medicina UNESP, Botucatu
dc.description.affiliationDepartamento de Patologia Faculdade de Medicina Universidade Estadual Paulista (UNESP), Botucatu, 18618-000, SP
dc.description.affiliationUnespDepartamento de Clnica Veterinria Faculdade de Medicina Veterinria e Zootecnia UNESP, Botucatu
dc.description.affiliationUnespDepartamento de Morfologia Instituto de Biologia UNESP, Botucatu
dc.description.affiliationUnespDepartamento de Patologia Faculdade de Medicina UNESP, Botucatu
dc.description.affiliationUnespDepartamento de Patologia Faculdade de Medicina Universidade Estadual Paulista (UNESP), Botucatu, 18618-000, SP
dc.format.extent103-111
dc.identifierhttp://dx.doi.org/10.1002/tcm.10008
dc.identifier.citationTeratogenesis Carcinogenesis and Mutagenesis, v. 22, n. 2, p. 103-111, 2002.
dc.identifier.doi10.1002/tcm.10008
dc.identifier.issn0270-3211
dc.identifier.lattes3278528112652257
dc.identifier.lattes6077735918469284
dc.identifier.orcid0000-0002-8188-8149
dc.identifier.scopus2-s2.0-0036179148
dc.identifier.urihttp://hdl.handle.net/11449/66850
dc.language.isoeng
dc.relation.ispartofTeratogenesis Carcinogenesis and Mutagenesis
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAgaricus bisporus
dc.subjectAnti-oxidants
dc.subjectComet assay
dc.subjectGanoderrna lucidum
dc.subjectReactive oxygen species
dc.subjectagaricus bisporus extract
dc.subjectAuricularia auricula extract
dc.subjectflammulina velutipes extract
dc.subjectGanoderma lucidum extract
dc.subjecthydrogen peroxide
dc.subjecthypsizygus mormoreus extract
dc.subjectlentinuloa edodes extract
dc.subjectleurotus sajor caju extract
dc.subjectmushroom derivative preparation
dc.subjectmushroom extract
dc.subjectplant extract
dc.subjectunclassified drug
dc.subjectvolvariella volvacea extract
dc.subjectantioxidant activity
dc.subjectDNA damage
dc.subjectgel electrophoresis
dc.subjectHong Kong
dc.subjecthuman
dc.subjecthuman cell
dc.subjectmushroom
dc.subjectmutagenesis
dc.subjectoxidative stress
dc.subjectpriority journal
dc.subjectAgaricales
dc.subjectComet Assay
dc.subjectDNA Damage
dc.subjectDNA, Neoplasm
dc.subjectFungal Proteins
dc.subjectHydrogen Peroxide
dc.subjectMutagenicity Tests
dc.subjectOxidation-Reduction
dc.subjectOxidative Stress
dc.subjectReactive Oxygen Species
dc.subjectTumor Cells, Cultured
dc.subjectAgaricus
dc.subjectAuricula
dc.subjectAuricularia auricula-judae
dc.subjectBasidiomycota
dc.subjectFlammulina
dc.subjectFlammulina velutipes
dc.subjectGanoderma
dc.subjectGanoderma lucidum
dc.subjectHypsizygus
dc.subjectHypsizygus marmoreus
dc.subjectLentinula
dc.subjectLentinula edodes
dc.subjectPleurotus
dc.subjectPleurotus sajor-caju
dc.subjectVolvariella volvacea
dc.titleMushroom-derived preparations in the prevention of H2O2-induced oxidative damage to cellular DNAen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dspace.entity.typePublication
unesp.author.lattes3278528112652257
unesp.author.lattes6077735918469284[1]
unesp.author.orcid0000-0002-8188-8149[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentPatologia - FMBpt
unesp.departmentMorfologia - IBBpt

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Botucatu - IBB - Instituto de Biociências
Botucatu - FMB - Faculdade de Medicina