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Betamethasone causes intergenerational reproductive impairment in male rats

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dc.contributor.authorBorges, Cibele dos Santos [UNESP]
dc.contributor.authorPacheco, Taina Louise [UNESP]
dc.contributor.authorda Silva, Katiussia Pinho [UNESP]
dc.contributor.authorFernandes, Fábio Henrique [UNESP]
dc.contributor.authorGregory, Mary
dc.contributor.authorPupo, André Sampaio [UNESP]
dc.contributor.authorSalvadori, Daisy Maria F. [UNESP]
dc.contributor.authorCyr, Daniel G.
dc.contributor.authorKempinas, Wilma De G. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Quebec
dc.date.accessioned2018-12-11T17:11:56Z
dc.date.available2018-12-11T17:11:56Z
dc.date.issued2017-08-01
dc.description.abstractPrenatal betamethasone (BM) exposure in rats negatively impacts sperm quality and male fertility. Studies have shown that BM can cause multi-generational effects on the pituitary-adrenal-axis of rats. The objective of this study was to assess the reproductive development and fertility of male rats (F2) whose fathers (F1) were exposed to BM (0.1 mg/kg) on gestational days 12, 13, 18 and 19. In F2 rats, there was a significant reduction in body weights of the BM-treated group at PND 1 as well as delayed onset of puberty, and decreases in FSH levels, Leydig cell volume, sperm number and motility, seminal vesicle contractility and ejaculated volume. Furthermore, increased serum LH levels, sperm DNA damage and abnormal morphology were observed, resulting in reduced fertility. In conclusion, prenatal BM-treatment leads to intergenerational long-term reproductive impairment in male rats, raising concern regarding the widespread use of BM in preterm births.en
dc.description.affiliationDepartment of Morphology Institute of Biosciences of Botucatu UNESP – São Paulo State University, Distrito de Rubião Junior s/nº
dc.description.affiliationDepartment of Pharmacology Institute of Biosciences of Botucatu UNESP – São Paulo State University, Distrito de Rubião Junior s/nº
dc.description.affiliationDepartment of Pathology Botucatu Medical School UNESP – São Paulo State University, Distrito de Rubião Junior s/n°
dc.description.affiliationLaboratory for Reproductive Toxicology INRS-Institut Armand-Frappier University of Quebec, 531 Boulevard des Prairies
dc.description.affiliationUnespDepartment of Morphology Institute of Biosciences of Botucatu UNESP – São Paulo State University, Distrito de Rubião Junior s/nº
dc.description.affiliationUnespDepartment of Pharmacology Institute of Biosciences of Botucatu UNESP – São Paulo State University, Distrito de Rubião Junior s/nº
dc.description.affiliationUnespDepartment of Pathology Botucatu Medical School UNESP – São Paulo State University, Distrito de Rubião Junior s/n°
dc.format.extent108-117
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2017.04.012
dc.identifier.citationReproductive Toxicology, v. 71, p. 108-117.
dc.identifier.doi10.1016/j.reprotox.2017.04.012
dc.identifier.file2-s2.0-85019189285.pdf
dc.identifier.issn1873-1708
dc.identifier.issn0890-6238
dc.identifier.scopus2-s2.0-85019189285
dc.identifier.urihttp://hdl.handle.net/11449/174578
dc.language.isoeng
dc.relation.ispartofReproductive Toxicology
dc.relation.ispartofsjr0,846
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBetamethasone intergenerational effects
dc.subjectFertility
dc.subjectPuberty onset
dc.subjectSeminal vesicle contractility
dc.subjectSperm quality
dc.titleBetamethasone causes intergenerational reproductive impairment in male ratsen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes2224433126054725[6]
unesp.author.orcid0000-0001-6627-3448[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentPatologia - FMBpt
unesp.departmentFarmacologia - IBBpt
unesp.departmentMorfologia - IBBpt

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Botucatu - IBB - Instituto de Biociências
Botucatu - FMB - Faculdade de Medicina