Publicação: Papel da regiao AV3V no choque septico experimental em ratos tratados com NaCl 7,5%
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
The effect of intravenous infusion of hypertonic saline (HS) on the recovery of mean arterial pressure (MAP) during septic shock was studied in sham-operated rats and in rats with electrolytic lesion in the anteroventral third ventricle (AV3V) region. Our results show that intravenous HS infusion in rats treated with endotoxin (Etx) partially restores MAP, but when we have a severe shock produced by Etx, HS was not able to reverse the hypotension. We also show that the integrity of the AV3V region is essential for the protective action of HS in endotoxin shock. It is possible that NO production contributes to the deleterious effect of endotoxin. So, the unraveling of the release of NO by the vascular endothelium and their role as regulators of vascular tone is increasing our understanding of the physiology and pathophysiology of the cardiovascular system and will therefore enhance the possibilities of preventing and treating endotoxin shock.
Descrição
Palavras-chave
7,5% NaCl, AV3V lesion and septic shock, endotoxin, hypertonic saline, nitric oxide, sodium chloride, animal experiment, animal model, blood pressure, blood vessel tone, brain region, brain ventricle, intracerebroventricular drug administration, nonhuman, rat, septic shock
Idioma
Português
Como citar
Revista de Ciencias Farmaceuticas, v. 17, p. 169-180.
