Publicação: Antimycobacterial activity of Indigofera suffruticosa with activation potential of the innate immune system
Nenhuma Miniatura disponível
Data
2010-08-01
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Taylor & Francis Inc
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
Mycobacterium tuberculosis is responsible for over 8 million cases of tuberculosis (TB) annually. Natural products may play important roles in the chemotherapy of TB. The antimycobacterial activity and the innate immune response of methanol (METH) and dichloromethane (DCM) extracts of Indigofera suffruticosa Miller (Fabaceae) were evaluated. We observed that the minimum inhibitory concentrations (MICs) for METH and DCM extracts were 125 and 1000 mu g/mL, respectively. However, they were able to induce the innate immune response through the production of high levels of NO and TNF-alpha (p < 0.001) by peritoneal exudate cells (PECs). These results suggest that I. suffruticosa extracts may have an important immunological role in the control of TB once macrophage activity is induced by them.
Descrição
Palavras-chave
Idioma
Inglês
Como citar
Pharmaceutical Biology. Philadelphia: Taylor & Francis Inc, v. 48, n. 8, p. 878-882, 2010.