In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides
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Numerous natural compounds have a potential for therapeutic applications, but may have to be chemically modified to alter toxic side effects. We investigated structural parameters that could affect the cytotoxicity of isocoumarins similar to 9,10-dihydroxy-5,7-dimethoxy-1H-naphtho(2,3c)pyran-1-one (paepalantine 1). Paepalantine 1 has antimicrobial activity, as well as significant in vitro cytotoxic effects in the McCoy cell line. Two other natural and two semi-synthetic isocoumarins with similar structures obtained from the capitula of Paepalanthus bromelioides were tested on the same cell line by the neutral red assay. Substitution of the 9 and/or 10-OH group made these compounds less cytotoxic.
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Cytotoxicity Activity Isocoumarin Paepalanthus bromelioides antiinfective agent cisplatin coumarin derivative angiosperm animal cell line cell survival chemistry drug effect fibroblast metabolism mouse structure activity relation Animals Anti-Infective Agents Cell Line Cell Survival Cisplatin Coumarins Fibroblasts Liliaceae Mice Structure-Activity Relationship
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Zeitschrift fur Naturforschung - Section C Journal of Biosciences, v. 57, n. 1-2, p. 85-88, 2002.
