Publicação: In vitro release of propolis from gelatin microparticles prepared by spray-drying technique
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The purpose of this study was to investigate the in vitro release of propolis from gelatin microparticles. Gelatin microparticles containing propolis extractive solution (PES) were prepared by spray-drying technique. Microparticles with a mean diameter of 2.50 μm and with regular morphology were obtained. The entrapment efficiency of propolis in the microparticles was over 39%. Spray-drying showed to be a feasible method for the preparation of gelatin microparticles containing propolis. Comparing to PES, the in vitro release of propolis from gelatin microparticles in aqueous medium was slower, considering markers 1 and 2. Thus, it was possible to transform a liquid propolis dosage form into a solid one, improving manipulation, packaging and storage and with modified release in aqueous medium, comparatively to the ethanolic extract of the drug.
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Gelatin, In vitro release, Microencapsulation, Microparticles, Propolis, Spray-drying, gelatin, nanoparticle, propolis, aqueous solution, drug release, feasibility study, in vitro study, morphology, spray drying, technique
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Inglês
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Revista de Ciencias Farmaceuticas, v. 25, n. 2, p. 79-84, 2004.
