Size-controlled hydroxyapatite particle nucleation in natural rubber latex membranes
Loading...
External sources
External sources
Date
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Type
Article
Access right
Acesso aberto
External sources
External sources
Abstract
Bone regeneration effectively treats fractures, but factors such as injury severity and age can delay healing. In these cases, implants or bone transplants may be required for repair. This study employed the biomimetic approach to fabricate composite membranes for bone tissue engineering. The inherent stretchability, barrier properties, and angiogenic potential of natural rubber latex were integrated with the excellent osteoconductive and osseointegrative properties of hydroxyapatite (HA). By controlling the biomimetic incubation, size-controlled CaP nucleation and growth within the latex matrix were achieved, ranging from nano to micro-scale. Characterization confirmed the successful formation of CaP-latex composites with enhanced surface roughness and wettability. Finally, the cytotoxicity analysis in fibroblasts showed that the Latex_CaP membranes were non-toxic. This combination of material properties offers significant potential for the development of advanced bone grafts with improved bioactivity and enhanced tissue regeneration.
Description
Keywords
Language
English
Citation
Materials Chemistry and Physics, v. 337.
