Publicação: Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol-Based beta-Amino Alcohol Derivatives
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Soc Brasileira Quimica
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Acesso aberto
Resumo
The synthesis of novel amino alcohol derivatives based on cardanol and glycerol were achieved in good yields and characterized by H-1 and C-13 NMR (nuclear magnetic resonance) and MS (mass spectrometry). In addition, we evaluated the in vitro antimicrobial activity against Gram-positive (Staphylococcus aureus, standard and clinical strains), Gram-negative (Escherichia coli) and M. tuberculosis bacterial strains. The bioassay results indicated that four compounds showed activity against S. aureus, including the clinical resistant strain, with MIC (minimum inhibitory concentration) ranging from 3.90 to 15.60 mu g mL(-1) and M. tuberculosis, with MIC90 (minimum inhibitory concentration required to inhibit the growth of 90% of organisms) ranging from 3.18 to 7.36 mu g mL(-1).
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CNSL, cardanol, amino alcohols, epoxide ring opening, antimicrobial activity
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Inglês
Como citar
Journal Of The Brazilian Chemical Society. Sao Paulo: Soc Brasileira Quimica, v. 29, n. 3, p. 639-648, 2018.
