Detection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosis
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Abstract
The 43,000-molecular-weight (43K) soluble glycoprotein was detected in sera of patients with paracoccidioidomycosis by the immunoblot technique by using as the probe rabbit monospecific antisera to this fraction. The 43K antigen was present before treatment in sera of patients with the acute (juvenile) form; it started to disappear from circulation after 10 months of chemotherapy, and it was undetectable afer 2 years of treatment. In the chronic cases, the 43K antigen was detected in patients without treatment, and it was absent in the healed cases. The detection of the 43K protein specific to Paracoccidioides brasiliensis may be important for its diagnostic value as well as for modulation of the host immune response.
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fungus antigen glycoprotein immunoglobulin g clinical article fungus human human cell immunoblotting nonhuman paracoccidioides brasiliensis priority journal serum south american blastomycosis Antigens, Fungal Chromatography, Affinity Electrophoresis, Polyacrylamide Gel Glycoproteins Human Immune Sera Immunoblotting Mitosporic Fungi Molecular Weight Paracoccidioides Paracoccidioidomycosis Support, Non-U.S. Gov't Time Factors Fungi Oryctolagus cuniculus Paracoccidioides brasiliensis
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English
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Journal of Clinical Microbiology, v. 27, n. 12, p. 2842-2845, 1989.
