Publicação: Synthesis and anti-Mycobacterium tuberculosis activity of vanadium complexes with N,N,O-donor ligands
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
John Libbey Eurotext
Tipo
Trabalho apresentado em evento
Direito de acesso
Resumo
Oxovanadium(IV) and dioxovanadium(V) complexes with Schiff base derivatives have been prepared, characterized and their in vitro antibacterial activities were evaluated against the Mycobacterium tuberculosis H37Rv ATCC 27294. The studied Compounds include the free ligands 2-acetylpyidine-N(4)-phenyl-semicarbazone (Happs), 2-acetylpyridine-2-aminobenzoylhydrazone (Hapah), 2-acetylpyridine-benzoylhydrazone (Hapbh) and 2-acetylpyridine-furanoylhydrazone (Hapfh) and the complexes [VO2(apps)] (1), [VO2(apah)] (2), [VO(acac)(apbh)] (3), [VO2(apbh)] (4), [VO(acac)(apfh)] (5) and [VO2(apfh)] (6), which were prepared from bis(acetylacetonate)oxovanadium(IV) [VO(acac)(2)] in MeOH. The vanadium compounds show in general higher anti-M. tuberculosis activities than the free ligands. Some of the complexes presented MIC values better than those observed for some commonly used anti-M. tuberculosis agents, in the range 31.25 to 0.97 (mu g/mL).
Descrição
Palavras-chave
vanadium(IV) and (V) complexes, schiff base ligands, Mycobacterium tuberculosis
Idioma
Inglês
Como citar
Metal Ions In Biology And Medicine, Vol 10. Montrouge: John Libbey Eurotext, v. 10, p. 197-+, 2008.
