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Synthesis and total 1H- and 13C-NMR assignment of cephem derivatives for use in ADEPT approaches

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dc.contributor.authorBlau, Lorena [UNESP]
dc.contributor.authorMenegon, Renato Farina [UNESP]
dc.contributor.authorFerreira, Elizabeth Igne
dc.contributor.authorFerreira, Antonio Gilberto
dc.contributor.authorBoffo, Elisangela Fabiana
dc.contributor.authorTavares, Leila Aley
dc.contributor.authorHeleno, Vladimir Constantino Gomes
dc.contributor.authorChung, Man-Chin [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade de Franca
dc.date.accessioned2014-05-27T11:23:31Z
dc.date.available2014-05-27T11:23:31Z
dc.date.issued2008-04-01
dc.description.abstractWe report the synthesis and total NMR characterization of 5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid-3-[[[(4″- nitrophenoxy)carbonyl]oxy]-methyl]-8-oxo-7-[(2-thienyloxoacetyl)amino] -diphenylmethyl ester-5-dioxide (5), a new cephalosporin derivative. This compound can be used as the carrier of a wide range of drugs containing an amino group. The preparation of the intermediate product, 5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylic acid-3-[methyl 4-(6-methoxyquinolin-8-ylamino) pentylcarbamate]-8-oxo-7-[(2-thienyloxoacetyl)amino]-diphenylmethyl ester-5-dioxide (6), as well as the synthesis of the antimalarial primaquine prodrug 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid-3-[methyl 4-(6-methoxyquinolin-8-ylamino)pentylcarbamate]-8-oxo-7-[(2-thienyloxoacetyl) amino]- 5-dioxide (7) are also described, together with their total 1H- and 13C-NMR assignments. © 2008 by MDPI.en
dc.description.affiliationDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, CP 502, 14801-902, Araraquara, SP
dc.description.affiliationDepartamento de Farmácia Faculdade de Ciências Farmacêuticas Universidade de São Paulo, CP 66083, 05389-970, São Paulo, SP
dc.description.affiliationDepartamento de Química Centro de Ciências Exatas e Tecnológicas Universidade Federal de São Carlos, CP 676, 13565-905, São Carlos, SP
dc.description.affiliationNúcleo de Pesquisas em Ciências Exatas e Tecnológicas Universidade de Franca, CP 82, 14404-600, Franca, SP
dc.description.affiliationUnespDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, CP 502, 14801-902, Araraquara, SP
dc.format.extent841-854
dc.identifierhttp://dx.doi.org/10.3390/molecules13040841
dc.identifier.citationMolecules. Basel: Molecular Diversity Preservation Int, v. 13, n. 4, p. 841-854, 2008.
dc.identifier.doi10.3390/molecules13040841
dc.identifier.file2-s2.0-43049167095.pdf
dc.identifier.issn1420-3049
dc.identifier.lattes9734333607975413
dc.identifier.orcid0000-0003-4141-0455
dc.identifier.scopus2-s2.0-43049167095
dc.identifier.urihttp://hdl.handle.net/11449/130528
dc.identifier.wosWOS:000255515900015
dc.language.isoeng
dc.publisherMolecular Diversity Preservation Int
dc.relation.ispartofMolecules
dc.relation.ispartofjcr3.098
dc.relation.ispartofsjr0,855
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subject1H, 13C and 2D NMR
dc.subjectADEPT
dc.subjectCancer
dc.subjectCephalosporin
dc.subjectProdrug
dc.subjectcephalosporin derivative
dc.subjectprimaquine
dc.subjectprodrug
dc.subjectchemistry
dc.subjectisomerism
dc.subjectnuclear magnetic resonance spectroscopy
dc.subjectsynthesis
dc.subjectCephalosporins
dc.subjectIsomerism
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectPrimaquine
dc.subjectProdrugs
dc.titleSynthesis and total 1H- and 13C-NMR assignment of cephem derivatives for use in ADEPT approachesen
dc.typeArtigopt
dcterms.licensehttp://www.mdpi.com/about/openaccess
dcterms.rightsHolderMolecular Diversity Preservation Int
dspace.entity.typePublication
relation.isDepartmentOfPublicatione214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isDepartmentOfPublication.latestForDiscoverye214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes9734333607975413[8]
unesp.author.orcid0000-0003-4141-0455[8]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas