Publicação: Synthesis and total 1H- and 13C-NMR assignment of cephem derivatives for use in ADEPT approaches
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Molecular Diversity Preservation Int
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Resumo
We report the synthesis and total NMR characterization of 5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid-3-[[[(4″- nitrophenoxy)carbonyl]oxy]-methyl]-8-oxo-7-[(2-thienyloxoacetyl)amino] -diphenylmethyl ester-5-dioxide (5), a new cephalosporin derivative. This compound can be used as the carrier of a wide range of drugs containing an amino group. The preparation of the intermediate product, 5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylic acid-3-[methyl 4-(6-methoxyquinolin-8-ylamino) pentylcarbamate]-8-oxo-7-[(2-thienyloxoacetyl)amino]-diphenylmethyl ester-5-dioxide (6), as well as the synthesis of the antimalarial primaquine prodrug 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid-3-[methyl 4-(6-methoxyquinolin-8-ylamino)pentylcarbamate]-8-oxo-7-[(2-thienyloxoacetyl) amino]- 5-dioxide (7) are also described, together with their total 1H- and 13C-NMR assignments. © 2008 by MDPI.
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1H, 13C and 2D NMR, ADEPT, Cancer, Cephalosporin, Prodrug, cephalosporin derivative, primaquine, prodrug, chemistry, isomerism, nuclear magnetic resonance spectroscopy, synthesis, Cephalosporins, Isomerism, Magnetic Resonance Spectroscopy, Primaquine, Prodrugs
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Inglês
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Molecules. Basel: Molecular Diversity Preservation Int, v. 13, n. 4, p. 841-854, 2008.
