Publicação: Involvement of the atrial natriuretic peptide in cardiovascular pathophysiology and its relationship with exercise
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In this minireview we describe the involvement of the atrial natriuretic peptide (ANP) in cardiovascular pathophysiology and exercise. The ANP has a broad homeostatic role and exerts complex effects on the cardio-circulatory hemodynamics, it is produced by the left atrium and has a key role in regulating sodium and water balance in mammals and humans. The dominant stimulus for its release is atrial wall tension, commonly caused by exercise. The ANP is involved in the process of lipolysis through a cGMP signaling pathway and, as a consequence, reducing blood pressure by decreasing the sensitivity of vascular smooth muscle to the action of vasoconstrictors and regulate fluid balance. The increase of this hormone is associated with better survival in patients with chronic heart failure (CHF). This minireview provides new evidence based on recent studies related to the beneficial effects of exercise in patients with cardiovascular disease, focusing on the ANP. © 2012 de Almeida et al; licensee BioMed Central Ltd.
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adenylate cyclase, aldosterone, angiotensin II, atrial natriuretic factor, beta adrenergic receptor blocking agent, catecholamine, cyclic GMP, endothelin, insulin, perilipin, renin, vasopressin, blood pressure, blood vessel tone, cardiovascular system, coronary artery disease, dehydration, disease course, enzyme activity, exercise, fluid balance, glomerulus filtration, heart failure, heart function, heart hemodynamics, heart left atrium, hormone determination, human, kidney function, kidney tubule absorption, lipolysis, nitrogen balance, pathophysiology, phosphorylation, prognosis, review, signal transduction, survival, urinary excretion, vascular resistance, vascular smooth muscle, vasoconstriction, venous oxygen tension
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International Archives of Medicine, v. 5, n. 1, 2012.
