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Publicação:
Macrophage activity and histopathology of the lymphohematopoietic organs in male Wistar rats orally exposed to single or mixed pesticides

dc.contributor.authorde Camargo, Marcela Rodrigues [UNESP]
dc.contributor.authorBarbisan, Luis Fernando [UNESP]
dc.contributor.authorMartinez, Meire França [UNESP]
dc.contributor.authorda Silva Franchi, Carla Adriene [UNESP]
dc.contributor.authorCamargo, João Lauro Viana de [UNESP]
dc.contributor.authorSpinardi-Barbisan, Ana Lúcia Tozzi [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:29:49Z
dc.date.available2014-05-27T11:29:49Z
dc.date.issued2013-07-01
dc.description.abstractThe noxious effects of low or effective dose exposure to single or mixed pesticides on macrophage activity and the lymphohematopoietic organs were investigated. Male Wistar rats were orally exposed to dichlorvos, dicofol, endosulfan, dieldrin and permethrin, either as single or combined mixtures during a 28-day study containing eight groups: one group received a semipurified diet (non-treated); two groups received a semipurified diet containing low dose mixture (dieldrin 0.025 mg/kg, endosulfan, 0.6 mg/kg, dicofol 0.22 mg/kg, dichlorvos 0.23 mg/kg, permethrin 5 mg/kg) or an effective dose mixture (dichlorvos 2.3 mg/kg, dicofol 2.5 mg/kg, endosulfan 2.9 mg/kg, dieldrin 0.05 mg/kg and permethrin 25.0 mg/kg), respectively; the other five groups received a semipurified diet containing each single pesticide in effective doses. At sacrifice, the thymus, spleen, mesenteric lymph nodes, Payer's patches and bone marrow were removed for histological analysis. Peritoneal macrophages were obtained to determine the phagocytosis and spreading indexes and tumoral necrosis factor alpha (TNF-α), nitric oxide (NO) and H2O2 production. Exposure to pesticide mixtures did not alter the percentage of macrophage phagocytosis and spreading, TNF-α production or the NO and H2O2 release when compared to the non-treated group. Neither was there any apparent evidence that a pesticide mixture at low or effective doses altered the histological structure of the lymphohematopoietic organs. The findings indicate that short-term treatment with pesticide mixtures did not induce an apparent immunotoxic effect in male Wistar rats. © 2013 Copyright Taylor and Francis Group, LLC.en
dc.description.affiliationDepartment of Pathology, Botucatu Medical School UNESP - Univ. Estadual Paulista, Botucatu, São Paulo State
dc.description.affiliationDepartment of Morphology Institute of Biosciences UNESP - Univ. Estadual Paulista, Botucatu, São Paulo State
dc.description.affiliationUnespDepartment of Pathology, Botucatu Medical School UNESP - Univ. Estadual Paulista, Botucatu, São Paulo State
dc.description.affiliationUnespDepartment of Morphology Institute of Biosciences UNESP - Univ. Estadual Paulista, Botucatu, São Paulo State
dc.format.extent607-613
dc.identifierhttp://dx.doi.org/10.1080/03601234.2013.775020
dc.identifier.citationJournal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes, v. 48, n. 7, p. 607-613, 2013.
dc.identifier.doi10.1080/03601234.2013.775020
dc.identifier.issn0360-1234
dc.identifier.issn1532-4109
dc.identifier.lattes3278528112652257
dc.identifier.scopus2-s2.0-84876273597
dc.identifier.urihttp://hdl.handle.net/11449/75787
dc.identifier.wosWOS:000317820900012
dc.language.isoeng
dc.relation.ispartofJournal of Environmental Science and Health - Part B: Pesticides, Food Contaminants, and Agricultural Wastes
dc.relation.ispartofjcr1.273
dc.relation.ispartofsjr0,420
dc.relation.ispartofsjr0,420
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectImmunotoxicity
dc.subjectlymphohematopoietic organs
dc.subjectmacrophage activity
dc.subjectmale rats
dc.subjectpesticide mixture
dc.subjectHistological analysis
dc.subjectHistological structure
dc.subjectMale rats
dc.subjectNecrosis factors
dc.subjectPeritoneal macrophage
dc.subjectPesticide mixture
dc.subjectAntigen-antibody reactions
dc.subjectChemical contamination
dc.subjectInsecticides
dc.subjectMacrophages
dc.subjectMixtures
dc.subjectNitric oxide
dc.subjectNutrition
dc.subjectPesticide effects
dc.subjectpesticide
dc.subjecttumor necrosis factor alpha
dc.subjectbone
dc.subjectdichlorvos
dc.subjectdieldrin
dc.subjectendosulfan
dc.subjecthistopathology
dc.subjectmale
dc.subjectnitric oxide
dc.subjectpermethrin
dc.subjectrodent
dc.subjectanimal
dc.subjectbone marrow
dc.subjectcell culture
dc.subjectdrug effect
dc.subjectimmunology
dc.subjectlymph node
dc.subjectlymphoid tissue
dc.subjectmacrophage
dc.subjectmacrophage activation
dc.subjectrat
dc.subjectspleen
dc.subjectthymus
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectBone Marrow
dc.subjectCells, Cultured
dc.subjectLymph Nodes
dc.subjectLymphoid Tissue
dc.subjectMacrophage Activation
dc.subjectMale
dc.subjectPesticides
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSpleen
dc.subjectThymus Gland
dc.subjectTumor Necrosis Factor-alpha
dc.titleMacrophage activity and histopathology of the lymphohematopoietic organs in male Wistar rats orally exposed to single or mixed pesticidesen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dspace.entity.typePublication
unesp.author.lattes3278528112652257
unesp.author.lattes9163387140787963[4]
unesp.author.orcid0000-0001-5768-2020[5]
unesp.author.orcid0000-0002-2830-2540[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentPatologia - FMBpt
unesp.departmentMorfologia - IBBpt

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