Agonistas do GnRH, antagonistas do GnRH e a reprodução assistida: Análogos do GnRH x fertilização in vitro
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Abstract
The agonists of gonadotropin-releasing hormone (GnRH) were introduced in ovarian stimulation for in vitro fertilization to avoid a premature surge of luteinizing hormone. Although they are accompanied by some disadvantages, GnRH agonists have become well accepted in clinical practice, and their use is associated with increased rates of pregnancy. The development of GnRH antagonists capable of blocking the pituitary immediately offered a therapeutic option. Comparative studies between the two analogs have suggested that the use of antagonists is associated with a shorter duration of ovulatory stimulus and a decreased incidence of ovarian hyperstimulation syndrome, while the type of GnRH analogues used show no significant effects on the rates of pregnancy and live birth. However, GnRH agonists have other applications in assisted reproductive technology cycles than the pituitary downregulation.
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Gnrh agonists , GnRH antagonists , In vitro fertilization , Ovarian stimulation , gonadorelin agonist , gonadorelin antagonist , luteinizing hormone , down regulation , fertilization in vitro , human , hypophysis , infertility therapy , live birth , luteinizing hormone release , ovary hyperstimulation , ovulation induction , pregnancy rate
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English
Citation
Jornal Brasileiro de Reproducao Assistida, v. 16, n. 3, p. 91-96, 2012.
