Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid
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Coadvisor
Graduate program
Undergraduate course
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Publisher
Wiley-Blackwell
Type
Article
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Acesso restrito
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Abstract
With the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium Il(tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.
Description
Keywords
potential tuberculostatic agent, isoniazid, prodrug, micelle-forming polymer, co-polymer poly(ethylene glycol)-poly(aspartic acid)
Language
German
Citation
Archiv Der Pharmazie. Berlin: Wiley-v C H Verlag Gmbh, v. 334, n. 6, p. 189-193, 2001.
