Publicação: 1.39 - Intestinal Dysbiosis in Autoimmune Diseases
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Evidence from animal models and humans suggests the role of intestinal dysbiosis in autoimmune disease development. Dysbiosis is associated with decreased microbiota function and diversity, increased intestinal permeability and pathobionts, and deregulated immune response. The proposed mechanisms to connect dysbiosis with autoimmunity include molecular mimicry, bystander T-cell activation, epitope spreading, post-translational modification of luminal proteins, and amplification by inflammatory cytokines. Probiotic bacteria favor the balance and maintenance of a healthy microbiota and epithelial barrier and directly impact systemic immunity, supporting their use in immune-mediated diseases. This article describes studies concerning dysbiosis and probiotics in autoimmune diseases.
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Autoimmunity, Dysbiosis, Graves' disease, Hashimoto thyroiditis, Inflammation, Microbiota, Probiotics, Rheumatoid arthritis, Sjögren syndrome, Systemic lupus erythematosus, Systemic sclerosis, Type 1 diabetes
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Comprehensive Gut Microbiota, v. 1, p. 545-563.
