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1.39 - Intestinal Dysbiosis in Autoimmune Diseases

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dc.contributor.authorde Oliveira, Gislane Lelis Vilela [UNESP]
dc.contributor.institutionHumanities and Exact Sciences
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:06:43Z
dc.date.available2023-07-29T13:06:43Z
dc.date.issued2022-01-01
dc.description.abstractEvidence from animal models and humans suggests the role of intestinal dysbiosis in autoimmune disease development. Dysbiosis is associated with decreased microbiota function and diversity, increased intestinal permeability and pathobionts, and deregulated immune response. The proposed mechanisms to connect dysbiosis with autoimmunity include molecular mimicry, bystander T-cell activation, epitope spreading, post-translational modification of luminal proteins, and amplification by inflammatory cytokines. Probiotic bacteria favor the balance and maintenance of a healthy microbiota and epithelial barrier and directly impact systemic immunity, supporting their use in immune-mediated diseases. This article describes studies concerning dysbiosis and probiotics in autoimmune diseases.en
dc.description.affiliationMicrobiology Program Institute of Biosciences Humanities and Exact Sciences, Sao Paulo
dc.description.affiliationDepartment of Food Engineering and Technology São Paulo State University (UNESP), Sao Paulo
dc.description.affiliationUnespDepartment of Food Engineering and Technology São Paulo State University (UNESP), Sao Paulo
dc.format.extent545-563
dc.identifierhttp://dx.doi.org/10.1016/B978-0-12-819265-8.00038-3
dc.identifier.citationComprehensive Gut Microbiota, v. 1, p. 545-563.
dc.identifier.doi10.1016/B978-0-12-819265-8.00038-3
dc.identifier.scopus2-s2.0-85151697775
dc.identifier.urihttp://hdl.handle.net/11449/247117
dc.language.isoeng
dc.relation.ispartofComprehensive Gut Microbiota
dc.sourceScopus
dc.subjectAutoimmunity
dc.subjectDysbiosis
dc.subjectGraves' disease
dc.subjectHashimoto thyroiditis
dc.subjectInflammation
dc.subjectMicrobiota
dc.subjectProbiotics
dc.subjectRheumatoid arthritis
dc.subjectSjögren syndrome
dc.subjectSystemic lupus erythematosus
dc.subjectSystemic sclerosis
dc.subjectType 1 diabetes
dc.title1.39 - Intestinal Dysbiosis in Autoimmune Diseasesen
dc.typeCapítulo de livro
dspace.entity.typePublication

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