Preparation and characterization of free films of high amylose/pectin mixtures cross-linked with sodium trimetaphosphate
Carregando...
Fontes externas
Fontes externas
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Informa Healthcare
Taylor & Francis
Taylor & Francis
Tipo
Artigo
Direito de acesso
Acesso restrito
Fontes externas
Fontes externas
Resumo
High amylose and pectin were mixed at 1: 1 mass ratio and cross-linked with sodium trimetaphosphate (STMP) in alkaline medium. Films were prepared from aqueous dispersions of these cross-linked polymer blend at three different concentrations (3, 4 and 5%), by solvent casting method. Characterization of the films included thickness, surface morphology, water uptake, water vapor permeability (WVP), tensile strength measurements and enzymatic digestion. The cross-linking allowed to obtain films with improved mechanical properties and reduced WVP. The high resistance to enzymatic digestion exhibited by these films represents a promising approach to their application in the development of colon drug delivery systems.
Descrição
Palavras-chave
Idioma
Inglês
Citação
Drug Development and Industrial Pharmacy. London: Informa Healthcare, v. 38, n. 11, p. 1354-1359, 2012.
