Interação das enterotoxinas estafilocócicas com o sistema imune do hospedeiro

Michelin, A. F. [UNESP]; Carlos, Iracilda Zeppone [UNESP]

Interação das enterotoxinas estafilocócicas com o sistema imune do hospedeiro

Date

2004-10-14

Authors

Michelin, A. F.

Carlos, Iracilda Zeppone

Type

Review

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Acesso restrito

Abstract

Staphylococcal enterotoxins are among the most common etiologic agents that cause food poisoning and, possibly, nonmenstrual toxic shock syndrome. These enterotoxins are also called superantigens because they are potent T cell and macrophages activators. The superantigens bind directly to the major histocompatibility complex class II molecules on antigen-presenting cells and stimulate T cells expressing specific Vβ elements in the cell receptors. Excessive production of cytokines by these cells and macrophages are responsible for the pathogenesis of food poisoning. These cytokine include tumor necrosis factor (TNF)-α, interferon (IFN)-γ and interleukin (IL)-1, proinflamatory mediators with potent immunoenhancing effects; the nitric oxide (NO). It still has both effects citotoxic and regulatory roles in immune function.

Keywords

Interferon-γ, Nitric oxide, Staphylococcal enterotoxins, Superantigens, Tumor necrosis factor-α, enterotoxin, gamma interferon, interleukin 1, major histocompatibility antigen class 2, nitric oxide, Staphylococcus enterotoxin, superantigen, tumor necrosis factor alpha, antigen presenting cell, cytokine production, food poisoning, immune system, immunomodulation, immunoregulation, macrophage activation, pathogenesis, review, septic shock, Staphylococcus, T lymphocyte