Publicação: Tigecycline: A Review of Properties, Applications, and Analytical Methods
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Lippincott Williams & Wilkins
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
Tigecycline is a new glycylcycline with an expanded broad-spectrum antibiotic, including inhibition of Gram-positive, Gram-negative, atypical, anaerobic, and antibiotic-resistant organisms. Trials have demonstrated that tigecycline is noninferior to the comparators for the treatment of complicated skin and skin structure infections as well as complicated intra-abdominal infections. Tigecycline is only available as an intravenous preparation and analytical methods to its quantitation in pharmaceutical products has not been published to date. This review examined tigecycline characteristics, the spectrum and mechanism of action, pharmacokinetics, applications, and, mainly, the instrumental conditions of published chromatographic methods used to measure tigecycline, its metabolites, and some analogs in clinical and biologic research.
Descrição
Palavras-chave
glycylcycline, tigecycline, analytical methods, broad-spectrum antibiotic
Idioma
Inglês
Como citar
Therapeutic Drug Monitoring. Philadelphia: Lippincott Williams & Wilkins, v. 32, n. 3, p. 282-288, 2010.
