Publicação:
MicroRNA and cancer: a focus on mammary tumors in female dogs

Carregando...
Imagem de Miniatura

Data

2018-01-01

Orientador

Coorientador

Pós-graduação

Curso de graduação

Título da Revista

ISSN da Revista

Título de Volume

Editor

Univ Federal Santa Maria

Tipo

Artigo

Direito de acesso

Acesso abertoAcesso Aberto

Resumo

Mammary tumors are the most frequent tumors reported in female dogs and have great relevance in veterinary oncology; however, little is known about the molecular mechanisms involved in the development of metastasis. An increasing number of human studies have suggested that epigenetic alterations, such as DNA methylation, miRNA, and histone modifications, are the predominant events leading to the metastatic phenotype in tumor cells and participate in regulating oncogenic signals associated with tumor spread. Among these epigenetic alterations, miRNAs have stood out in recent years, presenting a fundamental role in tumorigenesis. There are still few studies evaluating the role of miRNAs in canine mammary tissues. Thus, this paper aims to review the role of miRNAs in cancer with a special focus on canine mammary tumors.

Descrição

Idioma

Inglês

Como citar

Ciencia Rural. Santa Maria: Univ Federal Santa Maria, v. 48, n. 11, 6 p., 2018.

Itens relacionados

Financiadores

Unidades

Departamentos

Cursos de graduação

Programas de pós-graduação