Refining the intestinal motility test in mice to reduce animal stress
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A new protocol using 3-h fast animal for intestinal motility test was developed in our laboratory aiming the 3R's concept to reduce the stress of animals. Our results may aid in formulating recommendations that can be included in revised guidelines with regard to fasting time of mice.
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Animal welfare , In vivo test , Intestinal motility , Loperamide , Mice , loperamide , animal experiment , animal model , animal stress , animal testing reduction , animal testing refinement , animal testing replacement , animal tissue , animal welfare , clinical protocol , controlled study , diagnostic test , diet restriction , function test , in vivo study , intestine motility , intestine motility test , mouse , mouse strain , nonhuman , practice guideline , stress
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Revista de Ciencias Farmaceuticas, v. 24, n. 1, p. 79-82, 2003.
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