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Publicação:
Mitochondrial-related gene associated to obesity can be modulated by in utero hyperglycemic environment

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dc.contributor.authorSilveira, Maruhen A.D. [UNESP]
dc.contributor.authorMarcondes, João Paulo C. [UNESP]
dc.contributor.authorLara, Juliana R. [UNESP]
dc.contributor.authorScarano, Wellerson R. [UNESP]
dc.contributor.authorCalderón, Iracema M.P. [UNESP]
dc.contributor.authorRudge, Marilza V.C. [UNESP]
dc.contributor.authorSalvadori, Daisy M.F. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCentro Universitário Cesmac
dc.date.accessioned2019-10-06T16:18:43Z
dc.date.available2019-10-06T16:18:43Z
dc.date.issued2019-04-01
dc.description.abstractWe investigated whether mitochondrial-related genes and proteins are modulated by hyperglycemia promoted by gestational diabetes (GDM), thereby increasing neonate obesity predisposition. 19 healthy pregnant women, 16 pregnant women with GDM and their respective neonates were enrolled. Additionally, 19 obese and 19 eutrophic adults were recruited as a reference population. Umbilical cord, peripheral blood and placental (villous and decidua) tissues were collected to evaluate SOD2, PPAR-α and PPARGC-1β and their respective protein expressions. Data from the reference population confirmed that the three genes and proteins were overexpressed in blood cells of obese compared to eutrophic subjects. Only SOD2 was found upregulated in placental villous (fetal side) tissue of GDM women. Therefore, our findings showed an interaction between the hyperglycemic environment and SOD2 modulation, but also indicated that none of the three genes is useful as potential biomarkers for obesity development.en
dc.description.affiliationUNESP São Paulo State University Botucatu Medical School Department of Pathology, Botucatu
dc.description.affiliationCentro Universitário Cesmac
dc.description.affiliationUNESP São Paulo State University Institute of Biosciences Department of Morphology, Botucatu
dc.description.affiliationUNESP São Paulo State University Botucatu Medical School Department of Gynecology and Obstetrics, Botucatu
dc.description.affiliationUnespUNESP São Paulo State University Botucatu Medical School Department of Pathology, Botucatu
dc.description.affiliationUnespUNESP São Paulo State University Institute of Biosciences Department of Morphology, Botucatu
dc.description.affiliationUnespUNESP São Paulo State University Botucatu Medical School Department of Gynecology and Obstetrics, Botucatu
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent59-64
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2019.02.001
dc.identifier.citationReproductive Toxicology, v. 85, p. 59-64.
dc.identifier.doi10.1016/j.reprotox.2019.02.001
dc.identifier.issn1873-1708
dc.identifier.issn0890-6238
dc.identifier.scopus2-s2.0-85062029345
dc.identifier.urihttp://hdl.handle.net/11449/188771
dc.language.isoeng
dc.relation.ispartofReproductive Toxicology
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectFetal programming
dc.subjectGene expression
dc.subjectGestational diabetes
dc.subjectObesity
dc.subjectPlacenta
dc.titleMitochondrial-related gene associated to obesity can be modulated by in utero hyperglycemic environmenten
dc.typeArtigo
dspace.entity.typePublication
unesp.author.orcid0000-0003-4761-4336[5]
unesp.author.orcid0000-0001-9323-3134[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentGinecologia e Obstetrícia - FMBpt
unesp.departmentPatologia - FMBpt
unesp.departmentMorfologia - IBBpt

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Botucatu - FMB - Faculdade de Medicina
Botucatu - IBB - Instituto de Biociências