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Vasopressin and angiotensin receptors of the medial septal area of the brain in the control of thirst and salt appetite induced by vasopressin in water-deprived and sodium-depleted rats

dc.contributor.authorPavan de Arruda Camargo, Gabriela Maria
dc.contributor.authorde Arruda Camargo, Luiz Antonio
dc.contributor.authorSaad, Wilson Abrao
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2014-05-20T13:45:39Z
dc.date.available2014-05-20T13:45:39Z
dc.date.issued2007-10-01
dc.description.abstractIn this study we investigated the influence of d(CH2)(5)-Tyr (Me)-AVP (A(1) AVP) and [Adamanteanacatyl(1),D-ET-D-Tyr(2), Va1(4), aminobutyril(6) ,As-8,As-9]-AVP 9 (A(2)AVP), antagonists of V-1 and V-2 arginine(8)-vasopressin (AVP) receptors, respectively, as well as the effects of losartan and CGP42112A, antagonists of angiotensin II (ANGII) AT(1) and AT(2), receptors, respectively, on water and 0.3 M sodium intake induced by water deprivation or sodium depletion (furosemide treatment) and enhanced by AVP injected into the medial septal area (N4SA). A stainless steel carmulawas implanted into the medial septal area (NISA) of male Holtzman rats AVP injection enhanced water and sodium intake in a dose-dependent manner. Pretreatment with V-1 antagonist injected into the MSA produced a dose-dependent reduction, whereas prior injection of V-2 antagonist increased, in a dose-dependent manner, the water and sodium responses elicited by the administration of AVP. Both AT(1) and AT(2) antagonists administered into the MSA elicited a concentration-dependent decrease in water and sodium intake induced by AVP, while simultaneous injection of the two antagonists was more effective in decreasing AVP responses. These results also indicate that the increase in water and sodium intake induced by AvT was mediated primarily by MSA AT(1) receptors. (c) 2007 Published by Elsevier B.V.en
dc.description.affiliationSão Paulo State Univ, Sch Pharm, Dept Clin Anal, UNESP, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Dept Physiol, Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Sao Carlos, Dept Physiol, BR-13560 Sao Carlos, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Sch Pharm, Dept Clin Anal, UNESP, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Physiol, Araraquara, SP, Brazil
dc.format.extent393-399
dc.identifierhttp://dx.doi.org/10.1016/j.pbb.2007.05.013
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 87, n. 4, p. 393-399, 2007.
dc.identifier.doi10.1016/j.pbb.2007.05.013
dc.identifier.issn0091-3057
dc.identifier.urihttp://hdl.handle.net/11449/16071
dc.identifier.wosWOS:000249333400001
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.relation.ispartofjcr2.538
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.subjectarginine vasopressinpt
dc.subjectvasopressin V-1 antagonistpt
dc.subjectvasopressin V-2 antagonistpt
dc.subjectangiotensin AT(1) antagonistpt
dc.subjectangiotensin AT(2) antagonistpt
dc.subjectwater intakept
dc.subjectsodium intakept
dc.subjectmedial septal areapt
dc.titleVasopressin and angiotensin receptors of the medial septal area of the brain in the control of thirst and salt appetite induced by vasopressin in water-deprived and sodium-depleted ratsen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
relation.isDepartmentOfPublicationa83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isDepartmentOfPublicationb3ba3d9c-022e-4521-8805-0bcceea7372e
relation.isDepartmentOfPublication.latestForDiscoverya83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublicationca4c0298-cd82-48ee-a9c8-c97704bac2b0
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt
unesp.departmentFisiologia e Patologia - FOARpt

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