Esparfloxacino e as fluorquinolonas: Uma revisao de sua classificacao, atividade antibacteriana, mecanismo de acao, caracteristicas farmacocineticas, tolerabilidade e perspectivas farmaceuticas
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A revision was accomplished in the literature on the quinolones, antibacterial class that presents wide action spectrum, focusing, mainly, the sparfloxacin, third generation fluorquinolone which has potente activity against Gram positive organisms, including Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA), Gram negative organisms, Legionelia spp, Mycoplasma spp, Chlamydia spp and Mycobacterium spp, including multidrug resistant organisms.
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Antibacterial activity Fluoroquinolones Quinolones Sparfloxacin antiinfective agent ciprofloxacin fleroxacin irloxacin levofloxacin lomefloxacin nadifloxacin nalidixic acid norfloxacin ofloxacin pefloxacin pefloxacin mesilate pipemidic acid quinoline derived antiinfective agent quinolone derivative rufloxacin sparfloxacin trovafloxacin antibacterial activity drug distribution drug mechanism drug structure drug tolerability flatulence gastrointestinal symptom Gram positive bacterium human nonhuman review structure activity relation
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Português
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Revista de Ciencias Farmaceuticas, v. 20, n. 2, p. 301-333, 1999.
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