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Evaluation of Strychnos pseudoquina St. Hil. leaves extract on gastrointestinal activity in mice

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dc.contributor.authorAparecido Da Silva, Marcelo [UNESP]
dc.contributor.authorMurino Rafacho, Bruna Paola [UNESP]
dc.contributor.authorHiruma-Lima, Clelia Akiko [UNESP]
dc.contributor.authorMachado Da Rocha, Lúcia Regina [UNESP]
dc.contributor.authorCampaner Dos Santos, Lourdes [UNESP]
dc.contributor.authorSannomiya, Miriam [UNESP]
dc.contributor.authorMonteiro Souza-Brito, Alba Regina
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-27T11:21:24Z
dc.date.available2014-05-27T11:21:24Z
dc.date.issued2005-08-01
dc.description.abstractStrychnos pseudoquina St. Hil. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects. © 2005 Pharmaceutical Society of Japan.en
dc.description.affiliationDepartamento de Química Orgânica Instituto de Química UNESP, c.p. 355, CEP 14800-900, Araraquara, SP
dc.description.affiliationDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas UNESP, CEP 14800-900, Araraquara, SP
dc.description.affiliationDepartamento de Fisiologia Instituto de Biociências UNESP, c.p. 510, CEP 18618-000, Botucatu, SP
dc.description.affiliationDepartamento de Fisiologia e Biofísica Instituto de Biologia UNICAMP, c.p. 6109, CEP 13083-970, Campinas, SP
dc.description.affiliationUnespDepartamento de Química Orgânica Instituto de Química UNESP, c.p. 355, CEP 14800-900, Araraquara, SP
dc.description.affiliationUnespDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas UNESP, CEP 14800-900, Araraquara, SP
dc.description.affiliationUnespDepartamento de Fisiologia Instituto de Biociências UNESP, c.p. 510, CEP 18618-000, Botucatu, SP
dc.format.extent881-885
dc.identifierhttp://dx.doi.org/10.1248/cpb.53.881
dc.identifier.citationChemical and Pharmaceutical Bulletin, v. 53, n. 8, p. 881-885, 2005.
dc.identifier.doi10.1248/cpb.53.881
dc.identifier.issn0009-2363
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.scopus2-s2.0-24944567759
dc.identifier.urihttp://hdl.handle.net/11449/68357
dc.identifier.wosWOS:000231320700002
dc.language.isoeng
dc.relation.ispartofChemical and Pharmaceutical Bulletin
dc.relation.ispartofjcr1.258
dc.relation.ispartofsjr0,364
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectAlkaloid
dc.subjectAntiulcer activity
dc.subjectStrychnos pseudoquina
dc.subjectToxic activity
dc.subjectpiroxicam
dc.subjectplant extract
dc.subjectstrychnos pseudoquina extract
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectconcentration response
dc.subjectcontrolled study
dc.subjectdrug dose regimen
dc.subjectdrug effect
dc.subjectdrug isolation
dc.subjectdrug screening
dc.subjectin vivo study
dc.subjectmale
dc.subjectmedicinal plant
dc.subjectmortality
dc.subjectmouse
dc.subjectnonhuman
dc.subjectphytochemistry
dc.subjectplant leaf
dc.subjectstomach mucosa
dc.subjectstomach protection
dc.subjectstomach ulcer
dc.subjectstrychnos pseudoquina
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectDrug Evaluation, Preclinical
dc.subjectGastric Mucosa
dc.subjectMice
dc.subjectPlant Extracts
dc.subjectPlant Leaves
dc.subjectStomach Ulcer
dc.subjectStrychnos
dc.titleEvaluation of Strychnos pseudoquina St. Hil. leaves extract on gastrointestinal activity in miceen
dc.typeArtigopt
dcterms.licensehttp://bpb.pharm.or.jp/document/transfer.pdf
dspace.entity.typePublication
relation.isDepartmentOfPublicatione214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isDepartmentOfPublication.latestForDiscoverye214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes3814504901386844[3]
unesp.author.orcid0000-0002-8645-3777[3]
unesp.author.orcid0000-0003-3032-2556[8]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt
unesp.departmentFisiologia - IBBpt
unesp.departmentQuímica Orgânica - IQARpt

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Coleções

Araraquara - IQAR - Instituto de Química
Araraquara - FCF - Faculdade de Ciências Farmacêuticas
Botucatu - IBB - Instituto de Biociências