Evaluation of Strychnos pseudoquina St. Hil. leaves extract on gastrointestinal activity in mice
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Pharmaceutical Society of Japan
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Strychnos pseudoquina St. Hil. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects. © 2005 Pharmaceutical Society of Japan.
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Alkaloid , Antiulcer activity , Strychnos pseudoquina , Toxic activity , piroxicam , plant extract , strychnos pseudoquina extract , unclassified drug , animal experiment , animal model , animal tissue , concentration response , controlled study , drug dose regimen , drug effect , drug isolation , drug screening , in vivo study , male , medicinal plant , mortality , mouse , nonhuman , phytochemistry , plant leaf , stomach mucosa , stomach protection , stomach ulcer , strychnos pseudoquina , Animals , Anti-Inflammatory Agents, Non-Steroidal , Drug Evaluation, Preclinical , Gastric Mucosa , Mice , Plant Extracts , Plant Leaves , Stomach Ulcer , Strychnos
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Chemical and Pharmaceutical Bulletin, v. 53, n. 8, p. 881-885, 2005.
