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dc.contributor.authorGarcia, Valdir Gouveia [UNESP]
dc.contributor.authorLongo, M. [UNESP]
dc.contributor.authorGualberto Junior, E. C. [UNESP]
dc.contributor.authorBosco, Álvaro Francisco [UNESP]
dc.contributor.authorNagata, Maria José Hitomi [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorTheodoro, Letícia Helena [UNESP]
dc.date.accessioned2015-03-18T15:55:19Z
dc.date.available2015-03-18T15:55:19Z
dc.date.issued2014-10-01
dc.identifierhttp://dx.doi.org/10.1111/jre.12138
dc.identifier.citationJournal Of Periodontal Research. Hoboken: Wiley-blackwell, v. 49, n. 5, p. 584-594, 2014.
dc.identifier.issn0022-3484
dc.identifier.urihttp://hdl.handle.net/11449/117145
dc.description.abstractBackground and Objective: Antimicrobial therapy can suppress periodontal pathogens and increase the effectiveness of conventional mechanical treatment. The aim of this study was to assess bone loss and the immune inflammatory response of rats under the influence of two photosensitizing agents (MB and TBO) at two different concentrations in antimicrobial photodynamic therapy (aPDT), used as an adjuvant therapy in the treatment of periodontitis.Material and Methods: Periodontitis was induced in the mandibular first molars of 162 rats. The animals were divided into nine groups: G1 - scaling and root planing (SRP); G2 - SRP plus 100 mu g/mL of methylene blue (MB); G3 - SRP plus 10 mg/mL of MB; G4 - SRP plus 100 mu g/mL of toluidine blue (TBO); G5 - SRP plus 10 mg/mL of TBO; G6 - SRP plus 100 mu g/mL of MB and laser; G7 - SRP plus 10 mg/mL of MB and laser; G8 - SRP plus 100 mu g/mL of TBO and laser; and G9 - SRP plus 10 mg/mL of TBO and laser. Six animals from each group were euthanized 7, 15, or 30 d after treatment. Bone loss (BL) in the furcation region was evaluated using histomorphometric and immunohistochemical analyses to detect the receptor activator of nuclear factor-.appa B ligand (RANKL), osteoprotegerin (OPG) and tartrate-resistant acid phosphatase (TRAP).Results: There was significantly less BL in animals treated with aPDT using low concentrations of MB and TBO at 7, 15 and 30 d. Immunohistochemical analysis revealed decreased RANKL and increased OPG in the aPDT groups and decreased TRAP-positive cells in G6 and G8.Conclusions: aPDT, using low concentrations of MB and TBO, was the most effective adjuvant therapy to SRP, acting indirectly as a downregulator of the molecular mechanisms that control bone resorption in periodontitis.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent584-594
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Of Periodontal Research
dc.sourceWeb of Science
dc.subjectalveolar bone lossen
dc.subjectlasersen
dc.subjectperiodontitisen
dc.subjectphotochemotherapyen
dc.titleEffect of the concentration of phenothiazine photosensitizers in antimicrobial photodynamic therapy on bone loss and the immune inflammatory response of induced periodontitis in ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Ctr Educ Fdn Barretos
dc.description.affiliationSao Paulo State Univ UNESP, Dept Surg & Integrated Clin, Div Periodont, Grp Res & Study Laser Dent, Aracatuba, SP, Brazil
dc.description.affiliationUniv Ctr Educ Fdn Barretos, Dent Sch Barretos, Master Course, Barretos, SP, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Dept Basic Sci, Aracatuba, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Dept Surg & Integrated Clin, Div Periodont, Grp Res & Study Laser Dent, Aracatuba, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Dept Basic Sci, Aracatuba, SP, Brazil
dc.identifier.doi10.1111/jre.12138
dc.identifier.wosWOS:000341884200005
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 10/12570-8
dc.description.sponsorshipIdFAPESP: 10/13120-6
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt
dc.identifier.lattes4068921369233125
dc.identifier.lattes9831236034935598
dc.identifier.lattes8399870097572073
dc.identifier.lattes4408095517346846
dc.identifier.lattes4774447118127346
dc.identifier.orcid0000-0003-4859-0583
unesp.author.lattes4068921369233125
unesp.author.lattes9831236034935598
unesp.author.lattes8399870097572073
unesp.author.lattes4408095517346846[6]
unesp.author.lattes4774447118127346
unesp.author.orcid0000-0003-4859-0583[6]
unesp.author.orcid0000-0002-6715-8334[1]
dc.relation.ispartofjcr2.878
dc.relation.ispartofsjr0,927
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