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dc.contributor.authorBordon, Ana Paula
dc.contributor.authorDias-Melicio, Luciane Alarcao
dc.contributor.authorAcorci, Michele Janegitz
dc.contributor.authorBiondo, Guilherme Augusto
dc.contributor.authorFecchio, Denise [UNESP]
dc.contributor.authorPeraçoli, Maria Terezinha Serrão [UNESP]
dc.contributor.authorSoares, Ângela Maria Victoriano de Campos [UNESP]
dc.identifier.citationMycopathologia. Dordrecht: Springer, v. 163, n. 3, p. 129-135, 2007.
dc.description.abstractThe production of prostaglandins (PGs) during fungal infections could be an important suppressor factor of host immune response. Host cells are one source of prostaglandin E-2 (PGE(2)); however another potential source of PGE(2) is the fungal pathogen itself. Thus, both host and fungal PGE2 production is theorized to play a role in pathogenesis, being critical for growth of the fungus and to modulate the host immune response. The purpose of this work was to investigate if high and low virulent strains of Paracoccidioides brasiliensis have the capacity to produce PGE(2) in vitro, and if this production was related to the fungal growth. The results demonstrated that both strains of P. brasiliensis produce high levels of PGE(2) and the treatment with indomethacin, a cyclooxygenase inhibitor, significantly reduced the production of this mediator, as well as the viability of the fungus. Thus, our data indicate that PGE(2) is produced by P. brasiliensis by a cyclooxygenase-dependent metabolic pathway, and its production is required for fungal survival. This discovery reveals an important factor that has potentially great implications for understanding the mechanisms of immune deviation during infection.en
dc.sourceWeb of Science
dc.subjectprostaglandin E-2pt
dc.subjectParacoccidioides brasiliensispt
dc.subjectfungal growthpt
dc.titleProstaglandin E-2 production by high and low virulent strains of Paracoccidioides brasiliensisen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUNESP, Biosci Inst, Dept Microbiol & Immunol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUNESP, Sch Med, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Biosci Inst, Dept Microbiol & Immunol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Sch Med, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
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