Encapsulation of paclitaxel into a bio-nanocomposite. a study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
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Data
2015-01-01
Autores
Martins, Murillo L. [UNESP]
Orecchini, Andrea
Aguilera, Luis
Eckert, Juergen
Embs, Jan
Matic, Aleksander
Saeki, Margarida Juri [UNESP]
Bordallo, Heloisa N.
Frick, B.
Koza, M. M.
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E D P Sciences
Resumo
The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.
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Qens/wins 2014 - 11th International Conference On Quasielastic Neutron Scattering And 6th International Workshop On Inelastic Neutron Spectrometers. Cedex A: E D P Sciences, v. 83, 5 p., 2015.