Rank protein immunolabeling during bone-implant interface healing process
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Data
2010
Autores
Souza, Francisley Avila [UNESP]
Queiroz, Thallita Pereira
Luvizuto, Eloá Rodrigues
Nishioka, Renato Sussumu
Garcia-Jr, Idelmo Rangel
Carvalho, Paulo Sérgio Perri de
Okamoto, Roberta
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International Journal Of Dentistry
Resumo
The purpose of this paper was to evaluate the expression of RANK protein during bone-healing process around machined surface implants. Twenty male Wistar rats, 90 days old, after having had a 2 mm diameter and 6 mm long implant inserted in their right tibias, were evaluated at 7, 14, 21, and 42 days after healing. After obtaining the histological samples, slides were subjected to RANK immunostaining reaction. Results were quantitatively evaluated. Results. Immunolabeling analysis showed expressions of RANK in osteoclast and osteoblast lineage cells. The statistical analysis showed an increase in the expression of RANK in osteoblasts at 7 postoperative days and a gradual decrease during the chronology of the healing process demonstrated by mild cellular activity in the final stage (P < .05). Conclusion. RANK immunolabeling was observed especially in osteoclast and osteoblast cells in primary bone during the initial periods of bone-healing/implant interface.
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International Journal Of Dentistry, v. 2010, 2010.