The role of oxidative stress in renal injury related to obesity
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Data
2015
Autores
Pierine, Damiana Tortolero [UNESP]
Biondo, Guilherme Augusto [UNESP]
Silva, Vanessa dos Santos [UNESP]
Corrêa, Camila Renata [UNESP]
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Resumo
The mechanisms linking obesity to kidney damage are unknown. AGEs are responsible for renal damage in obese individuals. The receptor AGEs (RAGE) contributes to nuclear transcription factors that result in the production of proinflammatory cytokines and this seems to contribute to the development of renal disease. Thus, intervention with antioxidant can have an important effect in the prevention and treatment of pro-oxidant and pro-inflammatory state in the kidneys resulting from obesity.
Descrição
Palavras-chave
Obesity, Kidney, Oxidative stress, AGEs, RAGE, Inflammatory markers
Como citar
Inflammation & Cell Signaling, v. 2, p. 1-4, 2015.