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dc.contributor.authorGarcia Rosa, Ana Claudia
dc.contributor.authorSoares, Andresa Borges
dc.contributor.authorSantos, Fabricio Passador
dc.contributor.authorFuruse, Cristiane [UNESP]
dc.contributor.authorAraujo, Vera Cavalcanti de
dc.date.accessioned2018-11-27T22:14:30Z
dc.date.available2018-11-27T22:14:30Z
dc.date.issued2016-08-01
dc.identifierhttp://dx.doi.org/10.1111/jop.12402
dc.identifier.citationJournal Of Oral Pathology & Medicine. Hoboken: Wiley-blackwell, v. 45, n. 7, p. 494-499, 2016.
dc.identifier.issn0904-2512
dc.identifier.urihttp://hdl.handle.net/11449/165344
dc.description.abstractBACKGROUND: Polymorphous low-grade adenocarcinoma (PLGA) is a rare malignant tumor that usually arises in the minor salivary glands. Growth factors are cell-secreted peptides that regulate biological processes such as growth, proliferation, and differentiation. In salivary gland tumors, immunoexpression of growth factors and their receptors is associated with cell proliferation, malignant transformation, and tumor invasion. This study analyzed the expression of growth factors and receptors in PLGA, in other to better understand the mechanisms involved in the process of neoplastic cell proliferation and tumor progression. METHODS: The expression of growth factors FGF-2, PDGF-A, PDGF-B and receptors FGFR-1, FGFR-2, PDGFR-a, and EGFR was analyzed in 24 PLGA samples in comparison with normal salivary glands, by immunohistochemistry. A semi-quantitative analysis determined cell positivity in all stained sections. Scores were assigned according to percentage of reactive cells: score 0 < 10%; score 1-10 to 25%; score 2-25% to 50%; score 3- > 50%. The level of significance was set at 5%. RESULTS: Most of the growth factors and receptors, apart from FGFR-2, were significantly reactive in PLGA. Comparing to salivary acini, all of the reactive growth factors and receptors were significantly stronger in PLGA. Comparing to salivary ducts, the expression of FGF-2, PDGF-B, FGFR-1, and EGFR was significantly stronger in the nuclei and/or cytoplasm of the neoplastic cells. CONCLUSIONS: The increased expression of the growth factors and receptors in the PLGA, compared to normal salivary glands, may be related to cell proliferation, somehow participating in the oncogenic process.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent494-499
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Of Oral Pathology & Medicine
dc.sourceWeb of Science
dc.subjectEGFR
dc.subjectFGF
dc.subjectgrowth factors
dc.subjectPDGF
dc.subjectPolymorphous low-grade adenocarcinoma
dc.subjectsalivary glands
dc.titleImmunoexpression of growth factors and receptors in polymorphous low-grade adenocarcinomaen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
dc.contributor.institutionLutheran Univ Palmas
dc.contributor.institutionFed Univ Tocantins
dc.contributor.institutionSao Leopoldo Mandic Inst & Res Ctr
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationLutheran Univ Palmas, Dept Oral Pathol, Tocantins, Brazil
dc.description.affiliationFed Univ Tocantins, Dept Hlth Sci, Palmas, Tocantins, Brazil
dc.description.affiliationSao Leopoldo Mandic Inst & Res Ctr, Dept Oral Pathol, Campinas, SP, Brazil
dc.description.affiliationSao Paulo State Univ, Dept Oral Pathol, Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dept Oral Pathol, Sao Paulo, Brazil
dc.identifier.doi10.1111/jop.12402
dc.identifier.wosWOS:000385711900005
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 2015/12418-5
dc.relation.ispartofsjr0,791
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