Structure/activity of PtII/N,N-Disubstituted-N’-acylthiourea complexes: Anti-tumor and anti-mycobacterium tuberculosis activities
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Data
2018-06-01
Autores
Plutín, Ana M.
Alvarez, Anislay
Mocelo, Raúl
Ramos, Raúl
Sánchez, Osmar C.
Castellano, Eduardo E.
da Silva, Monize M.
Villarreal, Wilmer
Colina-Vegas, Legna
Pavan, Fernando R. [UNESP]
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Resumo
The syntheses, characterization, cytotoxicity against tumor cells and anti-Mycobacterium tuberculosis activity assays of PtII/PPh3/N,N-disubstituted-N’-acylthioureas complexes with general formulae [Pt(PPh3)2(L)]PF6, PPh3 = triphenylphosphine; L = N,N-disubstituted-N’-acylthiourea, are here reported. The complexes were characterized by elemental analysis, molar conductivity, infrared (IR), nuclear magnetic resonance (NMR) (1H, 13C{1H} and 31P{1H}) spectroscopy. The 31P{1H} NMR data are consistent with the presence of two PPh3 ligands cis to each other position, and one N,N-disubstituted-N’-acylthiourea coordinated to the metal through O and S, in a chelate form. The structures of the complexes were determined by X-ray crystallography, forming distorted square-planar structures. The complexes were tested in human cell lines carcinomas and also screened with respect to their anti-Mycobacterium tuberculosis activity (H37RvATCC 27294). It was found that complexes with N,N-disubstituted-N’-acylthiourea containing open and small chains as R2 groups show higher cytotoxic and higher anti-Mycobacterium tuberculosis activity than those containing rings in this position.
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Mycobacterium tuberculosis, Platinum(II), Tumor cells
Como citar
Journal of the Brazilian Chemical Society, v. 29, n. 6, p. 1256-1267, 2018.