Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology
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Data
2020-04-01
Autores
Andrade, Laise R. de
Tedesco, Antonio C.
Primo, Fernando L. [UNESP]
Farias, Gabriel R.
Silva, Jaqueline R. da
Longo, Joao P. F.
Almeida, Marcos C. de
Souza, Paulo E. N. de
Azevedo, Ricardo B. de
Pinheiro, Willie O.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Future Medicine Ltd
Resumo
Aim: Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer. Materials & methods: Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-term effect of NanoALA-PDT on tumor progression were performed. Results: The nanoformulation favored the prodrug uptake by tumor cells in a shorter time (1.5 h). As a result, the adverse effects were negligible and the response rates for primary mammary tumor control were significantly improved. Tumor progression was slower after NanoALA-PDT treatment, providing longer survival. Conclusion: NanoALA is a good proactive drug candidate for PDT against cancer potentially applied as adjuvant/neoadjuvant intervention strategy for breast cancer.
Descrição
Palavras-chave
4T1 cells, 5-aminolevulinic acid, breast cancer, photodynamic therapy, polymeric nanoemulsion
Como citar
Nanomedicine. London: Future Medicine Ltd, v. 15, n. 10, p. 1019-1036, 2020.