Spirocyclic lactams and curvulinic acid derivatives from the endophytic fungus Curvularia lunata and their antibacterial and antifungal activities
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Data
2020-03-01
Autores
Hilario, Felipe [UNESP]
Polinário, Giulia [UNESP]
de Amorim, Marcelo Rodrigues [UNESP]
de Sousa Batista, Victor [UNESP]
do Nascimento Júnior, Nailton Monteiro [UNESP]
Araújo, Angela Regina [UNESP]
Bauab, Taís Maria [UNESP]
dos Santos, Lourdes Campaner [UNESP]
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Resumo
Curvularia lunata, isolated from the capitula of Paepalanthus chiquitensis (Eriocaulaceae), was cultured in potato dextrose broth (PDB) medium. The ethyl acetate extract yielded two new spirocyclic γ-lactams (3 and 4), and five known compounds, namely: triticones E (1) and F (2), 5-O-methylcurvulinic acid (5), curvulinic acid (6) and curvulin (7). Their structures were elucidated by spectroscopic analysis and by the comparison with literature data. Besides, a computational study was used to elucidate the absolute configuration of the C − 3′ in the compounds (3) and (4). The extract and the compounds (1 and 2), (6) and (7) were assayed against gram-positive and gram-negative bacteria and fluconazole-resistant yeast. The triticones (1) and (2) showed good antibacterial activity for Escherichia coli, with a minimum inhibitory concentration of 62.5 μg/mL.
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Antibacterial activity, Curvularia lunata, Curvulinic acid, Paepalanthus chiquitensis, Spirocyclic lactams
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Fitoterapia, v. 141.