Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats
Data
2019-10-07
Autores
Mulinari-santos, Gabriel [UNESP]
Santos, Jaqueline Silva Dos [UNESP]
Palin, Letícia Pitol [UNESP]
Silva, Ana Cláudia Ervolino Da [UNESP]
Antoniali, Cristina [UNESP]
Faverani, Leonardo Perez [UNESP]
Okamoto, Roberta [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Faculdade De Odontologia De Bauru - USP
Resumo
Hypertension is one of the main causes of premature death in the world; also, it is associated with several bone alterations. Preclinical studies have demonstrated delayed alveolar bone healing in hypertensive rats. However, losartan has been favorable for consolidation of bone grafts and reduction in active periodontitis. Therefore, losartan is suggested to be effective in bone formation stages, as well as in the synthesis of matrix proteins and mineralization.
Descrição
Palavras-chave
Losartan, Spontaneously hypertensive rats, Bone, Hypertension
Como citar
Journal of Applied Oral Science. Faculdade De Odontologia De Bauru - USP, v. 27, p. -, 2019.