Publicação: Polyoxyethylene 9-lauryl ether-solubilized alkaline phosphatase: Synergistic stimulation by zinc and magnesium ions
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1. 1. Polidocanol-solubilized apoalkaline phosphatase could be stimulated either by zinc ions (Kd = 8.5 nM) or by magnesium ions alone (Kd = 3.8 μM). 2. 2. Zinc and magnesium ions had synergistic effects on Polidocanol-solubilized apoalkaline phosphatase, leading to a fully active enzyme (700-800 U/mg). 3. 3. Zinc ions inhibited non-competitively the Polidocanol-solubilized apoenzyme (Ki = 7.1 μM) by displacing magnesium ions from their binding sites. 4. 4. A model for the action of zinc and magnesium ions on the modulation of the enzyme activity is proposed. © 1992.
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International Journal of Biochemistry, v. 24, n. 4, p. 611-615, 1992.
