Microbiological assay for lomefloxacin in coated tablets
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The validation of a microbiological assay, applying cylinder plate method for determination of the activity of lomefloxacin in coated tablets is described. Using a strain of Bacillus subtilis ATCC 9372 as the test organism, lomefloxacin was measured in concentrations ranging from 2.0 to 8.0 μg/mL. The method validation showed that it is linear (r= 0.9999), precise (relative standard deviation = 1.15%), and accurate (it measured the added quantities). The excipients did not interfere in the determination. It was concluded that the microbiological assay is satisfactory for quantitation of lomefloxacin in tablets.
How to cite this document
Gomes, Greici Cristiani; Salgado, Hérida Regina Nunes. Microbiological assay for lomefloxacin in coated tablets. Journal of AOAC International, v. 89, n. 4, p. 1077-1079, 2006. Available at: <http://hdl.handle.net/11449/231800>.