Microbiological assay for lomefloxacin in coated tablets

Nenhuma Miniatura disponível

Data

2006-01-01

Autores

Gomes, Greici Cristiani [UNESP]
Salgado, Hérida Regina Nunes [UNESP]

Título da Revista

ISSN da Revista

Título de Volume

Editor

Resumo

The validation of a microbiological assay, applying cylinder plate method for determination of the activity of lomefloxacin in coated tablets is described. Using a strain of Bacillus subtilis ATCC 9372 as the test organism, lomefloxacin was measured in concentrations ranging from 2.0 to 8.0 μg/mL. The method validation showed that it is linear (r= 0.9999), precise (relative standard deviation = 1.15%), and accurate (it measured the added quantities). The excipients did not interfere in the determination. It was concluded that the microbiological assay is satisfactory for quantitation of lomefloxacin in tablets.

Descrição

Palavras-chave

Como citar

Journal of AOAC International, v. 89, n. 4, p. 1077-1079, 2006.