Adjuvant Therapy with 1% Alendronate Gel for Experimental Periodontitis Treatment in Rats
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Data
2021-01-01
Autores
Kajimoto, Natália De Campos
Buischi, Yvonne De Paiva
Loomer, Peter Michael
Bromage, Timothy G.
Ervolino, Edilson [UNESP]
Fucini, Stephen Enrico
Pola, Natália Marcumini
Pirovani, Beatriz Ommati [UNESP]
Morábito, Maria Juliana Sismeiro [UNESP]
de Almeida, Juliano Milanezi [UNESP]
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Resumo
Purpose: The aim of this study was to evaluate the effects of locally delivered 1% alendronate (ALN) gel used as an adjunct to non-invasive periodontal therapy. Methods: Ligature-induced periodontitis was performed in 96 rats. The ligature was tied in the cervical area of the mandibular left first molar. The animals were randomly divided into 4 groups: 1) NT, no treatment; 2) SRP, scaling and root planning; 3) SRP/PLA, SRP followed by filling the periodontal pocket with placebo gel (PLA); and 4) SRP/ALN, SRP followed by filling the periodontal pockets with 1% ALN gel. Histomorphometric (percentage of bone in the furcation region [PBF]) and immunohistochemical (receptor activator of nuclear factor-κB ligand, osteoprotegerin, and tartrate-resistant acid phosphatase) analyses were performed. Data were statistically analyzed, with the threshold of statistical significance set at P≤0.05. Results: The SRP, SRP/PLA, and SRP/ALN groups presented a higher PBF than the NT group (P≤0.01) at 7, 15, and 30 days. The SRP/ALN group presented a higher PBF than the SRP/PLA group in all experimental periods, as well as a higher PBF than the SRP group at 15 and 30 days. No differences were observed in the immunohistochemical analyses (P>0.05 for all). Conclusions: Locally delivered 1% ALN gel used as an adjunct to SRP enhanced bone regeneration in the furcation region in a rat model of experimental periodontitis.
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Alendronate, Dental scaling, Periodontal disease, Periodontitis, Rats
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Journal of Periodontal and Implant Science, v. 51, p. 1-12.