Development of a pressure nociceptive threshold testing device for evaluation of analgesics in cats
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Data
2007-02-01
Autores
Dixon, M. J.
Taylor, P. M.
Steagall, P. V. M.
Brondani, J. T.
Luna, Stélio Pacca Loureiro [UNESP]
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Editor
W B Saunders Co Ltd
Resumo
A pressure analgesiometric device was developed for unrestrained cats. Eleven cats were studied. Stimulation was via three rounded pins within a bracelet on the forearm. The pins were advanced by manual bladder inflation. Bladder pressure was measured using a strain gauge pressure transducer. The threshold was recorded at the behavioural end point. Thresholds were measured at 5 and 15 min intervals for 2-4 h, after removal/replacement of the cuff, for 120 min after SC butorphanol (0.4 mg/kg), and with mild skin inflammation at the testing site. Data were analysed using ANOVA. Pressure thresholds in untreated cats were around 150 mmHg. The minimum interval for testing was established as 15 min. Data were reproducible over 4 h and beyond 24 h. Thresholds in 5 cats increased (P < 0.05) above baseline for 45 min after butorphanol with a maximum increase of 270 +/- 182 mmHg at 10 min. Thresholds decreased with inflammation. The method appears suitable for feline analgesia investigations. (c) 2006 Elsevier Ltd. All rights reserved.
Descrição
Palavras-chave
pressure threshold, cat, analgesia, pain, equipment, measurement, pressure nociceptive threshold testing, opioid, NSAID
Como citar
Research In Veterinary Science. London: W B Saunders Co Ltd, v. 82, n. 1, p. 85-92, 2007.