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dc.contributor.authorMarques, M. F. [UNESP]
dc.contributor.authorCarlos, Iracilda Zeppone [UNESP]
dc.date.accessioned2014-05-27T11:21:14Z
dc.date.available2014-05-27T11:21:14Z
dc.date.issued2004-12-01
dc.identifier.citationRevista de Ciencias Farmaceuticas, v. 25, n. 1, p. 31-35, 2004.
dc.identifier.issn0101-3793
dc.identifier.urihttp://hdl.handle.net/11449/68049
dc.description.abstractThe immunological response includes wide contexts involving several cells, and the macrophage is crucial in the cellular immune response. Several stimuli to macrophage membrane may induce the liberation of H2O2, contributing to antibacterial and cytotoxicical actions. Nowadays, there is a tendency to study natural products to verify their capacity of acting in the immune system. This study evaluated the citotoxicity of the bulk extract and the hexanic and acetic fractions extracted from Styrax camporum Pohl (Styracaceae) and the production of H2O2, on murine peritonal macrophages cultures exposed to fractions extracted from this plant. The results showed that the fraction HX 2 mg/ml produced the liberation of H 2O2 in high concentrations and to 4 mg/ml was observed high citotoxicity. The fractions AC did not produce the liberation of H 2O2 and EB was produced in low levels. We conclude that this HX is a potent stimulator of macrophage.en
dc.format.extent31-35
dc.language.isopor
dc.relation.ispartofRevista de Ciencias Farmaceuticas
dc.sourceScopus
dc.subjectCytotoxicity
dc.subjectHydrogen peroxide
dc.subjectMacrophage
dc.subjectStyrax camporum
dc.subjecthydrogen peroxide
dc.subjectplant extract
dc.subjectStyrax camporum extract
dc.subjectunclassified drug
dc.subjectanimal cell
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectevaluation
dc.subjectextraction
dc.subjectimmune response
dc.subjectimmune system
dc.subjectmedicinal plant
dc.subjectmembrane transport
dc.subjectnonhuman
dc.subjectperitoneum macrophage
dc.subjectstyrax camporum
dc.titleCitotoxicidade de Styrax camporum Pohl em macrófagos peritoneais e a liberação de H2O2pt
dc.title.alternativeCitotoxicity of Styrax camporum Pohl in peritoneal macrophages and H 2O2 liberationen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationDepartamento de Análises Clínicas Faculdade de Ciências Farmacêuticas UNESP, 14801-902 - Araraquara - SP
dc.description.affiliationUnespDepartamento de Análises Clínicas Faculdade de Ciências Farmacêuticas UNESP, 14801-902 - Araraquara - SP
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-27444440528
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
dc.identifier.lattes1730146818754269
unesp.author.lattes1730146818754269
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