Lack of inhibitory effect of zinc on prolactin secretion induced by cimetidine
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Data
2005-06-01
Autores
Castro, A. V. B. [UNESP]
Mendonça, B. B.
Bloise, W.
Shuhama, T.
Brandão-Neto, J.
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Resumo
The dopaminergic, serotoninergic and GABA-ergic systems are closely involved in PRL secretion, as well as thyrotropin-releasing hormone. There is some evidence that zinc interacts with some of these neuroamines and neuropeptides. The histamine H2-receptor cimetidine stimulates PRL secretion rapidly following an intravenous injection in man. In this sense, we investigated probable inhibitory effect of zinc on prolactin secretion following cimetidine injection (300 mg). Therefore, we studied five healthy adult men, before and after oral zinc administration (25 mg elemental zinc) during three consecutive months. The results did not demonstrate any inhibitory effect of zinc on prolactin secretion. So, we originally concluded that zinc did not interact with dopamine, serotonine, gamma-aminobutyric acid and the thyrotropin-releasing hormone in humans. In addition, the intravenous administration of cimetidine did not change the serum zinc profile. © 2005 Dustri-Vertag Dr. K. Feistle.
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Cimetidine tolerance test, Healthy men, Neurotransmitters, Prolactin secretion, Zinc tolerance test, 4 aminobutyric acid, cimetidine, dopamine, histamine H2 receptor, prolactin, protirelin, serotonin, zinc, adult, controlled study, correlation analysis, diet supplementation, dopaminergic transmission, drug effect, drug mechanism, histamine release, hormone action, human, human experiment, male, normal human, priority journal, prolactin release, serotoninergic system, side effect, zinc blood level
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Trace Elements and Electrolytes, v. 22, n. 2, p. 133-138, 2005.