Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production

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Data

2009-10-01

Autores

Carlos, Iracilda Z. [UNESP]
Carli, Camila B. A. [UNESP]
Maia, Danielle C. G. [UNESP]
Benzatti, Fernanda P. [UNESP]
Lopes, Flavia C. M. [UNESP]
Roese, Fernanda M.
Watanabe, Márcio
Micheletti, Ana C.
Santos, Lourdes Campaner dos [UNESP]
Vilegas, Wagner [UNESP]

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Resumo

The effects of isolated compounds from Brazilian lichens and their derivatives on H 2O 2 and NO production were studied using murine macrophages as a part of an attempt to understand their possible immunomodulatory properties. The compound cytotoxicity was studied using MTT assay. Macrophage stimulation was evaluated by the determination of NO (Griess assay) and H 2O 2 (horseradish peroxidase/phenol red) in supernatants of peritoneal macrophage cultures of Swiss mice. This research demonstrated stimulatory activities of some phenolic compounds isolated from lichens and their derivatives on H 2O 2 and NO production. Structure-activity relationships suggest several synthetic directions for further improvement of immunological activity.

Descrição

Palavras-chave

Hydrogen peroxide, Lichens, Macrophages, Nitric oxide, Phenolic compounds, 8' o n propyl norstitic acid, 9' o ethyl norstitic acid, 9' o ethyl protocetraric acid, 9' o iso propyl protocetraric acid, 9' o methyl protocetraric acid, 9' o n butyl protocetraric acid, 9' o n hexyl protocetraric acid, 9' o n pentyl protocetraric acid, 9' o n propyl protocetraric acid, 9' o sec butyl protocetraric acid, 9' o terc butyl protocetraric acid, comprotocetraric acid, hydrogen peroxide, immunostimulating agent, lichexanthone, methyl protocetrate, nitric oxide, nitroblue tetrazolium, norstitic acid, phenol derivative, physodic acid, protocetraric acid, unclassified drug, animal cell, cell stimulation, cell viability, cytotoxicity, drug determination, drug structure, drug synthesis, immune response, immunomodulation, lichen, macrophage, mouse, nonhuman, peritoneum, structure activity relation, supernatant, Swiss Webster mouse

Como citar

Brazilian Journal of Pharmacognosy, v. 19, n. 4, p. 847-852, 2009.